About the Product: Tonebone total is special bone building formula and all ingredients like calcium citrate. Calcitrol, vitamin k2-7, omega-3, work synergistically to promote bone health. The bone health declines due to loss of calcium from bones thereby causing bone diseases like osteoporosis, osteopenia and post-menopausal osteoporosis (fall of estrogen level after menopause, results in calcium depletion from bones)
Bone Loss Causes:
- Ageing—Reduced bone strength because more bones are broken than can be made (osteopenia)
- Alcohol—Risk of osteoporosis for excessive alcoholic person.
- Eating unhealthy junk food with aerated drinks can lead to bone loss.
- Hormones—Post menopause due to sudden drop in estrogen level leads to depletion of calcium from bones.
- Low level of vitamin D level results in poor absorption
Rationale of Combination: Tonebone Total contain calcitriol which is active metabolite of vitamin D as it enables the body absorb calcium but when given in combination with vitamin K2-7, it directs the calcium to the part where it is needed, thereby preventing toxicity of calcium. Omega in combination with boron increases bone strength, Calcium citrate along with calcitriol reduces bone fractures in the elderly.
Calcium Citrate Maleate: Tonebone total contain calcium citrate which is soluble form of calcium. Calcium citrate is made by mixing calcium salt in citric acid with malic acid and is better then other alkaline form of calcium like calcium carbonate. Since it gets absorbed in cell membrane which increases its bio availability thereby increasing the bone density. There is no risk of kidney stone with calcium citrate and have good safety profile.
Mechanism: Calcium citrate increases calcium absorption at the intestine and retention at kidney level thereby increasing serum calcium level and reducing serum phosphate level. Calcium citrate even get absorbed without gastric acid.
Omega 3: Omega-3 fatty acids are found in fatty layers of cold-water fish and shellfish, plant and nut oils.
There are the two main types of omega-3 fatty acids in Tonebone Total:
Long-chain omega-3 fatty acids are EPA (eicosapentaenoic acid) and DHA (Docosahexaenoic acid). EPA and DHA, are beneficial for bone metabolism. Omega 3 is useful for increasing bone formation, affecting peak bone mass in adolescents and reducing bone loss, thereby reducing risk of osteoporosis. Omega-3s is useful in treating arthritis. Patients taking omega-3 supplements have reported reduced joint pain and increased grip strength.
Mechanism: Omega 3 in Tonebone Total helps in absorption of calcium in the body thus increasing bone mass and prevents loss of calcium in the urine, thereby increasing the bone strength and enhances bone growth. It decreases the number and activity of bone destroying cells therefore reducing inflammation and reduces poist menopausal osteoporosis.
Calcitriol .25 mcg: Tonebone Total contain calcitriol, which is synthetic man-made active form of vitamin D & active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. Most people get enough vitamin D from exposure to the sun and from fortified food products (e.g., dairy products, vitamins). Vitamin D helps control parathyroid hormone and the levels of certain minerals (e.g., calcium, phosphorus) that are needed for building and keeping strong bones.
Mechanism: Calcitriol increases blood calcium levels by enhancing absorption of calcium from the intestine and also increases renal tabular reabsorption of calcium, thereby reducing loss of calcium in the urine.
Vitamin K2-7: Vitamin K2-7 plays very important role for long term bone health. It increases the bone density and reduces risk of osteoporosis, Vitamin K2-7 helps other minerals to bind to bone matrix and good for long term bone health. K2-7 has the ability to reverse the bone loss.
Boron: Boron in Tonebone Total is essential trace element for strengthening the bones. It keeps the skeletal structure strong as it ensures proper metabolism and utilization of bone building factors. Boron also ensures less loss of calcium in the urine and helps body to utilize calcitriol in a better way thus promoting healthy bone formation.
Indication: Osteoporosis, osteopenia, post-menopausal osteoporosis, maintaining calcium level to strengthen the bones, overall bone health
Storage Condition: To be stored in a cool place, no direct sunlight and moisture
Side Effects: Headache, Dry mouth
Dosage: OD dosage or as directed by physician.